Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29282163 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL2555371 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL931815 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL4588453 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL19402669 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL16329219 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL22445115 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL22445005 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| Hydrochloric Acid SCHEMBL28335348 | 0.97 | MEN1 (0.55) | MEN1KMT2ATSHRMAPK1CAMK2A | |
| SCHEMBL46587 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566057-B2 | Long-acting co-agonists of the glucagon and GLP-1 receptors | MERCK SHARP & DOHME LLC (US) | 2023-01-31 | — | — | US | disclosed |
| US-11566057-B2 | Long-acting co-agonists of the glucagon and GLP-1 receptors | MERCK SHARP & DOHME LLC (US) | 2023-01-31 | — | — | US | disclosed |
| EP-3700550-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | Merck Sharp & Dohme Corp. (US) | 2020-09-02 | — | — | EP | disclosed |
| US-20200270325-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2020-08-27 | — | — | US | disclosed |
| US-20200270325-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2020-08-27 | — | — | US | disclosed |
| CN-111132690-A | Long-acting co-agonists of glucagon and GLP-1 receptor | 默沙东公司 | 2020-05-08 | — | — | CN | disclosed |
| WO-2019060660-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019060660-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566057-B2 | Long-acting co-agonists of the glucagon and GLP-1 receptors | GLP1R, GCGR, GIPR | MEN1 897/4885KMT2A 3576/4885TSHR 43/4885 |
| US-20200270325-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | GLP1R, GCGR, GIPR | MEN1 897/4885KMT2A 3576/4885TSHR 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.