SCHEMBL20845008

SCHEMBL20845008

Cc1ccc(-c2noc(C3CC(F)(I)C3)n2)cc1NC(=O)c1cnc2ccc(COCC(F)F)cn12

nearest known ligand 0.90

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14738513 0.95 KIT (1.00) KIT
SCHEMBL21387413 0.90 KIT (0.83) KIT
SCHEMBL14739121 0.89 KIT (0.82) KIT
SCHEMBL14758884 0.89 KIT (0.82) KIT
SCHEMBL14738108 0.86 KIT (1.00) KIT
SCHEMBL14739527 0.86 KIT (1.00) KIT
SCHEMBL14739237 0.86 KIT (1.00) KIT
SCHEMBL14738823 0.86 KIT (1.00) KIT
SCHEMBL14738549 0.85 KIT (0.84) KIT
SCHEMBL14738950 0.85 KIT (1.00) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751102-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-03-27 EP disclosed