Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926381 | 0.98 | PARP1 (0.72) | PARP1ALDH1A1PDE10ALMNAALOX12 | |
| SCHEMBL8491580 | 0.85 | CCR1 (0.57) | PARP1ALDH1A1LMNAALOX12NR4A1 | |
| SCHEMBL1697020 | 0.84 | PARP1 (0.55) | PARP1ALDH1A1LMNAALOX12KDM4E | |
| SCHEMBL8489852 | 0.83 | PARP1 (0.56) | PARP1ALDH1A1PDE10ALMNAALOX12 | |
| SCHEMBL8490761 | 0.83 | PARP1 (0.53) | PARP1ALDH1A1LMNAALOX12NR4A1 | |
| SCHEMBL8493517 | 0.83 | PARP1 (0.53) | PARP1ALDH1A1LMNAALOX12NR4A1 | |
| SCHEMBL14007366 | 0.80 | PIM1 (0.58) | PARP1ALDH1A1PIM1 | |
| SCHEMBL8491258 | 0.80 | PARP1 (0.49) | PARP1ALDH1A1LMNAALOX12NR4A1 | |
| SCHEMBL27860057 | 0.80 | PARP1 (0.49) | PARP1ALDH1A1LMNAALOX12NR4A1 | |
| SCHEMBL29412561 | 0.77 | PARP1 (0.72) | PARP1ALDH1A1ALOX12NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057053-A1 | FUSED RING DERIVATIVE USED AS FGFR4 INHIBITOR | 北京加科思益新药研发有限公司 | 2019-03-28 | — | — | WO | disclosed |
| CN-102532101-B | 2-(quinoline-8-yl)benzimidazole derivative | UNIV JIANGNAN | 2014-02-19 | — | — | CN | disclosed |
| CN-103360414-A | Quinoline rare earth complex, catalyst and polymerization method | QINGDAO YIKESI NEW MATERIAL CO LTD | 2013-10-23 | — | — | CN | disclosed |
| CN-102532101-A | 2-(quinoline-8-yl)benzimidazole derivative | UNIV JIANGNAN | 2012-07-04 | — | — | CN | disclosed |
| CN-102532100-A | 1-alkyl-2-(quinolone-8-yl) benzimidazole derivative | UNIV JIANGNAN | 2012-07-04 | — | — | CN | disclosed |