Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 10/20 | 0.59 |
| ▸ | CDK2 | P24941 | 7/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.59 |
| ▸ | CCNH | P51946 | 5/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.59 |
| ▸ | CDK1 | P06493 | 5/20 | 0.59 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24791521 | 0.90 | CCNE1 (0.57) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24181327 | 0.88 | CDK7 (0.47) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL22611879 | 0.87 | CDK7 (0.63) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24791694 | 0.86 | CCNE1 (0.51) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792867 | 0.85 | CDK2 (0.68) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL20848287 | 0.84 | CDK7 (0.57) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL20848283 | 0.82 | CDK7 (0.48) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL20848290 | 0.81 | CDK7 (0.61) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792780 | 0.81 | CDK2 (0.60) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL23562151 | 0.80 | CDK7 (0.53) | CDK7CDK2CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684769-B1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AS CDK INHIBITORS | CARRICK THERAPEUTICS LTD (IE) | 2022-01-12 | — | — | EP | disclosed |
| WO-2021122745-A1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2021-06-24 | — | — | WO | disclosed |
| WO-2019057825-A1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AS CDK INHIBITORS | Carrick Therapeutics Limited (IE) | 2019-03-28 | — | — | WO | disclosed |