Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.46 |
| ▸ | CTSD | P07339 | 8/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.46 |
| ▸ | REN | P00797 | 4/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27750729 | 0.88 | BACE1 (0.37) | BACE1CTSDBACE2RENCHRM5 | |
| SCHEMBL2086072 | 0.86 | BACE1 (0.49) | BACE1CTSDBACE2CHRM5KCNH2 | |
| SCHEMBL12785481 | 0.85 | BACE1 (0.43) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL2086155 | 0.84 | BACE1 (0.46) | BACE1CTSDBACE2CHRM5KCNH2 | |
| SCHEMBL2086695 | 0.83 | BACE1 (0.64) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL2086604 | 0.83 | BACE1 (0.67) | BACE1CTSDBACE2RENCHRM5 | |
| SCHEMBL2084875 | 0.80 | BACE1 (0.43) | BACE1BACE2KCNH2 | |
| SCHEMBL2086162 | 0.80 | BACE1 (0.57) | BACE1CTSDBACE2KCNH2 | |
| Trifluoroacetic Acid SCHEMBL2085829 | 0.79 | BACE1 (0.41) | BACE1CTSDBACE2RENCHRM5 | |
| SCHEMBL3549272 | 0.78 | BACE1 (0.68) | BACE1CTSDBACE2RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059992-A1 | New Compounds | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20110059992-A1 | New Compounds | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20110059992-A1 | New Compounds | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-7855213-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-12-21 | — | — | US | disclosed |
| US-7855213-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-12-21 | — | — | US | disclosed |
| US-7855213-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-12-21 | — | — | US | disclosed |
| EP-2035378-A1 | SUBSTITUTED ISOINDOLES AS BACE INHIBITORS AND THEIR USE | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| US-20080171771-A1 | New Compounds 391 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| US-20080171771-A1 | New Compounds 391 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| US-20080171771-A1 | New Compounds 391 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| WO-2007149033-A1 | SUBSTITUTED ISOINDOLES AS BACE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007149033-A1 | SUBSTITUTED ISOINDOLES AS BACE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059992-A1 | New Compounds | MAPT, PSEN2, PSEN1 | BACE1 5/4885CTSD 1916/4885BACE2 18/4885 |
| US-20080171771-A1 | New Compounds 391 | PSEN2, PSEN1, MAPT | BACE1 4/4885CTSD 1715/4885BACE2 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.