Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959573 | 0.79 | BRD4 (0.41) | BRD4BRD2CRBNALDH1A1GRM5 | |
| SCHEMBL7438008 | 0.79 | CRBN (0.41) | BRD4BRD2PLA2G7CRBNALDH1A1 | |
| SCHEMBL28134558 | 0.76 | MAPK1 (0.32) | — | |
| SCHEMBL21517152 | 0.72 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL17433536 | 0.72 | BRD4 (0.68) | BRD4BRD2CRBNALDH1A1GAA | |
| SCHEMBL17433520 | 0.72 | BRD4 (0.68) | BRD4BRD2CRBNALDH1A1GAA | |
| SCHEMBL24245002 | 0.71 | BRD4 (0.54) | BRD4BRD2 | |
| SCHEMBL5257727 | 0.71 | BRD4 (0.43) | BRD4BRD2ALDH1A1 | |
| SCHEMBL17433534 | 0.69 | BRD4 (0.56) | BRD4BRD2PLA2G7CRBNGAA | |
| SCHEMBL9020969 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020206424-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2019060742-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC (US) | 2019-03-28 | — | — | WO | disclosed |