Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16786082 | 1.00 | PREP (0.48) | PREPACE2NPSR1 | |
| SCHEMBL16786076 | 0.95 | PREP (0.49) | PREPACE2NPSR1 | |
| SCHEMBL16786078 | 0.82 | PREP (0.49) | PREPACE2NPSR1 | |
| SCHEMBL20986848 | 0.80 | SMN1; SMN2 (0.49) | NPSR1 | |
| SCHEMBL5866405 | 0.79 | SMN1; SMN2 (0.57) | NPSR1 | |
| SCHEMBL21193695 | 0.78 | PREP (0.55) | PREPACE2NPSR1 | |
| SCHEMBL3011829 | 0.78 | PREP (0.56) | PREPACE2NPSR1 | |
| SCHEMBL10310512 | 0.78 | PREP (0.56) | PREPACE2NPSR1 | |
| SCHEMBL16764330 | 0.78 | JAK3 (0.33) | — | |
| SCHEMBL21193181 | 0.78 | PREP (0.54) | PREPACE2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200079754-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2020-03-12 | — | — | US | disclosed |
| US-20190100505-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079754-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | PREP 4236/4885ACE2 4141/4885NPSR1 4459/4885 |
| US-20190100505-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | PREP 4053/4885ACE2 3694/4885NPSR1 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.