Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21061853 | 0.86 | MAPT (0.47) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16840450 | 0.84 | MAPT (0.46) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25309557 | 0.83 | MAPT (0.45) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21061555 | 0.83 | MAPT (0.45) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18255889 | 0.81 | MAPT (0.44) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16841463 | 0.80 | MAPT (0.49) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4251805 | 0.80 | MAPT (0.49) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4251803 | 0.80 | MAPT (0.49) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL880005 | 0.80 | MAPT (0.43) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9986149 | 0.80 | MAPT (0.46) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662245-A | Synthesis method of ethyl-3-oxylidene-1-oxa-4-azaspiro [5.5] undecane-9-formic acid ester | 上海合全药物研发有限公司 | 2020-09-15 | — | — | CN | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |