Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gonadorelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR known ✓ | P30968 | 3/20 | 0.87 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.94 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.85 |
| ▸ | APLNR | P35414 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gonadorelin SCHEMBL29371269 | 0.99 | PTGS1 (0.96) | PTGS1GNRHRABCC2APLNR | |
| Gonadorelin SCHEMBL29351373 | 0.99 | PTGS1 (0.96) | PTGS1GNRHRABCC2APLNR | |
| Gonadorelin SCHEMBL22520 | 0.99 | PTGS1 (0.96) | PTGS1GNRHRABCC2APLNR | |
| Gonadorelin SCHEMBL29359962 | 0.98 | PTGS1 (0.93) | PTGS1GNRHRABCC2APLNR | |
| Gonadorelin SCHEMBL20856308 | 0.97 | PTGS1 (0.93) | PTGS1GNRHRABCC2APLNR | |
| Triptorelin SCHEMBL30022783 | 0.97 | PTGS1 (1.00) | PTGS1GNRHRABCC2APLNR | |
| Triptorelin SCHEMBL29903080 | 0.97 | PTGS1 (1.00) | PTGS1GNRHRABCC2APLNR | |
| Triptorelin SCHEMBL19712233 | 0.97 | PTGS1 (1.00) | PTGS1GNRHRABCC2APLNR | |
| SCHEMBL29384641 | 0.96 | PTGS1 (0.90) | PTGS1GNRHRABCC2APLNR | |
| Fertirelin SCHEMBL31351846 | 0.96 | GNRHR (0.95) | PTGS1GNRHRABCC2APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3639856-B1 | LONG-ACTING PALMITIC ACID-CONJUGATED GNRH DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | NOVEL PHARMA INC (KR) | 2022-08-03 | — | — | EP | disclosed |
| CN-111093709-B | Long-acting palmitic acid conjugated GnRH derivatives and pharmaceutical compositions containing the same | 新型医药公司 | 2021-11-12 | — | — | CN | disclosed |
| US-10994018-B2 | Long-acting palmitic acid-conjugated GnRH derivative, and pharmaceutical composition containing same | NOVEL PHARMA INC. (KR) | 2021-05-04 | — | — | US | disclosed |
| US-20200268896-A1 | LONG-ACTING PALMITIC ACID-CONJUGATED GnRH DERIVATIVE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | NOVEL PHARMA INC. (KR) | 2020-08-27 | — | — | US | disclosed |
| CN-111093709-A | Long-acting palmitic acid conjugated GnRH derivatives and pharmaceutical compositions containing the same | 新型医药公司 | 2020-05-01 | — | — | CN | disclosed |
| EP-3639856-A1 | LONG-ACTING PALMITIC ACID-CONJUGATED GnRH DERIVATIVE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Novel Pharma Inc. (KR) | 2020-04-22 | — | — | EP | disclosed |
| WO-2019066199-A1 | LONG-ACTING PALMITIC ACID-CONJUGATED GnRH DERIVATIVE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 주식회사 제이피바이오지 | 2019-04-04 | — | — | WO | disclosed |