Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 6/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 6/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17681733 | 0.78 | AXL (0.43) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL17681732 | 0.75 | PRKCI (0.49) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL17681735 | 0.72 | PRKCI (0.45) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL17681725 | 0.71 | AXL (0.44) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL12563103 | 0.70 | PRKCI (0.54) | PRKCIAXLCCNKCDK12TTBK1 | |
| SCHEMBL12563113 | 0.70 | PRKCI (0.62) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL1356886 | 0.69 | PRKCI (0.67) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL12346326 | 0.68 | JAK1 (0.46) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL1468505 | 0.66 | PRKCI (0.53) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL21855862 | 0.66 | PRKCI (0.53) | PRKCIAXLCCNKCDK12JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204374-B1 | ISOINDOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-04-03 | — | — | EP | disclosed |