Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | CSF1R | P07333 | 1/20 | 0.74 |
| ▸ | RET | P07949 | 1/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.74 |
| ▸ | KIT | P10721 | 1/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.74 |
| ▸ | CDK11B | P21127 | 1/20 | 0.74 |
| ▸ | CCNC | P24863 | 1/20 | 0.74 |
| ▸ | FLT4 | P35916 | 1/20 | 0.74 |
| ▸ | CDK8 | P49336 | 1/20 | 0.74 |
| ▸ | BTK | Q06187 | 1/20 | 0.74 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.74 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.74 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683870 | 0.99 | FLT3 (0.75) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683710 | 0.89 | FLT3 (0.75) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL20873194 | 0.88 | FLT3 (0.77) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683748 | 0.88 | FLT3 (0.72) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL20873204 | 0.87 | FLT3 (0.75) | FLT3LCKCSF1RRETPDGFRB | |
| Iodide SCHEMBL23190190 | 0.86 | FLT3 (0.56) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683595 | 0.86 | FLT3 (0.70) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683698 | 0.86 | FLT3 (0.88) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683620 | 0.86 | FLT3 (0.68) | FLT3LCKCSF1RRETPDGFRB | |
| SCHEMBL19683615 | 0.86 | FLT3 (0.68) | FLT3LCKCSF1RRETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |