Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | RARA | P10276 | 4/20 | 0.43 |
| ▸ | RARB | P10826 | 4/20 | 0.43 |
| ▸ | RARG | P13631 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20876234 | 0.88 | BRD4 (0.48) | BRD4RARARARBRARGALDH1A1 | |
| SCHEMBL29595685 | 0.86 | RARB (0.47) | BRD4RARARARBRARGALDH1A1 | |
| SCHEMBL20887711 | 0.86 | RARB (0.47) | BRD4RARARARBRARGALDH1A1 | |
| SCHEMBL28741192 | 0.79 | BRD4 (0.39) | BRD4ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL28741195 | 0.79 | BRD4 (0.39) | BRD4ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL20876267 | 0.78 | BRD4 (0.50) | BRD4ALDH1A1ALOX5PTGS1PTGS2 | |
| SCHEMBL20876244 | 0.78 | BRD4 (0.52) | BRD4RARARARBRARGALDH1A1 | |
| SCHEMBL23705376 | 0.76 | RARB (0.51) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL20887547 | 0.76 | RARB (0.47) | BRD4RARARARBRARGALDH1A1 | |
| SCHEMBL29596210 | 0.76 | RARB (0.47) | BRD4RARARARBRARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319307-B2 | 2,3-dihydrobenzohurans as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2022-05-03 | — | — | US | disclosed |
| US-20200291009-A1 | 2,3-DIHYDROBENZOFURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2020-09-17 | — | — | US | disclosed |
| EP-3692036-A1 | 2,3-DIHYDROBENZOFURANS AS BOROMODOMAIN INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019068782-A1 | 2,3-DIHYDROBENZOFURANS AS BOROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291009-A1 | 2,3-DIHYDROBENZOFURANS AS BROMODOMAIN INHIBITORS | BRD4, BRPF3, BRD3 | BRD4 1/4885RARA 3293/4885RARB 2176/4885 |
| US-11319307-B2 | 2,3-dihydrobenzohurans as bromodomain inhibitors | BRD4, BRD3, BRPF3 | BRD4 1/4885RARA 3071/4885RARB 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.