Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4389761 | 0.90 | MAPK14 (0.55) | MAPK14 | |
| SCHEMBL13602982 | 0.90 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL28458651 | 0.89 | MAPK14 (0.55) | MAPK14 | |
| Trifluoroacetic Acid SCHEMBL20876999 | 0.89 | MAPK14 (0.57) | MAPK14 | |
| Trifluoroacetic Acid SCHEMBL4379674 | 0.88 | MAPK14 (0.62) | MAPK14 | |
| SCHEMBL4379260 | 0.87 | MAPK14 (0.57) | MAPK14 | |
| SCHEMBL13602984 | 0.87 | MAPK14 (0.68) | MAPK14 | |
| Trifluoroacetic Acid SCHEMBL4379256 | 0.85 | MAPK14 (0.61) | MAPK14 | |
| Trifluoroacetic Acid SCHEMBL4379273 | 0.83 | MAPK14 (0.57) | MAPK14 | |
| SCHEMBL13602983 | 0.83 | MAPK14 (0.65) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3691620-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019071147-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2019-04-11 | — | — | WO | disclosed |