Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896617 | 0.90 | KDM5B (0.42) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL16896604 | 0.86 | KDM5B (0.40) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL22781038 | 0.80 | KDM5B (0.43) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL16899196 | 0.76 | IRAK4 (0.37) | KDM5BMCL1RXRARXRBRXRG | |
| SCHEMBL29533406 | 0.72 | KDM5B (0.47) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL25183152 | 0.72 | KDM5B (0.42) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL30336044 | 0.72 | KDM5B (0.42) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL16896639 | 0.71 | CYP4F2 (0.48) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL29505407 | 0.71 | CYP4F2 (0.48) | KDM5BMCL1FLT3SYKAURKB | |
| SCHEMBL23535740 | 0.71 | MCL1 (0.47) | KDM5BMCL1FLT3FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466955-A1 | METHOD OF PREPARING OXAZOLO[4,5-B]PYRIDINE AND THIAZOLO[4,5-B]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS FOR TREATING CANCER | Aurigene Discovery Technologies Limited (IN) | 2019-04-10 | — | — | EP | disclosed |