⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20892923 | 0.94 | HRH3 (0.30) | — | |
| SCHEMBL19727312 | 0.81 | — | — | |
| SCHEMBL19727296 | 0.81 | — | — | |
| SCHEMBL19727289 | 0.81 | — | — | |
| SCHEMBL19763794 | 0.81 | — | — | |
| SCHEMBL19727291 | 0.79 | HRH3 (0.31) | — | |
| SCHEMBL19727288 | 0.79 | HRH3 (0.31) | — | |
| SCHEMBL19727290 | 0.79 | HRH3 (0.31) | — | |
| SCHEMBL24244468 | 0.77 | — | — | |
| SCHEMBL19727297 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10870652-B2 | Compounds and methods for modulating bruton's tyrosine kinase | CORVUS PHARMACEUTICALS, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190106423-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS BIOPHARMACEUTICALS, LTD. (KY) | 2019-04-11 | — | — | US | disclosed |