Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.49 |
| ▸ | FAP | Q12884 | 6/20 | 0.49 |
| ▸ | POU2F2 | P09086 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | POU2F1 | P14859 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12650019 | 0.92 | DPP4 (0.51) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL20895837 | 0.89 | DPP4 (0.48) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL20895836 | 0.89 | DPP4 (0.48) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL19154499 | 0.89 | DPP4 (0.48) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL1772436 | 0.88 | DPP4 (0.63) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL13955147 | 0.81 | DPP4 (0.42) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL10030473 | 0.81 | DPP4 (0.50) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL13954913 | 0.81 | DPP4 (0.50) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL2976376 | 0.81 | DPP4 (0.50) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL8273215 | 0.80 | DPP4 (0.61) | DPP4FAPPOU2F2ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190434-B1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2019-04-17 | — | — | EP | claimed |