⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534586 | 0.98 | TSHR (0.43) | — | |
| SCHEMBL1416162 | 0.98 | TSHR (0.43) | — | |
| SCHEMBL1415947 | 0.92 | — | — | |
| SCHEMBL2746597 | 0.87 | TSHR (0.52) | — | |
| SCHEMBL2059697 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL2136691 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL31296577 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL2746089 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL5721317 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL2139712 | 0.84 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-B1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | claimed |
| EP-0957908-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-03-12 | — | — | EP | claimed |
| EP-1023295-A4 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO INC (US) | 2001-01-24 | — | — | EP | claimed |
| EP-1061934-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-12-27 | — | — | EP | claimed |
| EP-1023295-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | claimed |
| EP-0957908-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1999-11-24 | — | — | EP | claimed |
| US-5981584-A | USEFUL IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING THE AGGREGATION OF BLOOD PLATELETS, INHIBITING ANGIOGENESIS, INHIBITING OSTEOCLAST MEDIATED BONE RESORPTION, PREVENTING PLATELET THROMBOSIS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | claimed |
| WO-1999045939-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-09-16 | — | — | WO | claimed |
| US-5945545-A | SUBSTITIUTED AMIDINOBENZENE COMPOUNDS; ANTICOAGULANTS | MERCK & CO., INC. (US) | 1999-08-31 | — | — | US | claimed |
| WO-1998034935-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | claimed |
| WO-1998025601-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | claimed |
| US-8163753-B2 | 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | OTSUKA PHAMACEUTICAL CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-5981584-A | USEFUL IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING THE AGGREGATION OF BLOOD PLATELETS, INHIBITING ANGIOGENESIS, INHIBITING OSTEOCLAST MEDIATED BONE RESORPTION, PREVENTING PLATELET THROMBOSIS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1999045939-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-09-16 | — | — | WO | disclosed |
| US-5945545-A | SUBSTITIUTED AMIDINOBENZENE COMPOUNDS; ANTICOAGULANTS | MERCK & CO., INC. (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998034935-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | disclosed |
| WO-1998025601-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |