Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 17/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070406 | 0.80 | RET (0.56) | CYP11B2RET | |
| SCHEMBL20137068 | 0.79 | RET (0.46) | CYP11B2RET | |
| SCHEMBL20069889 | 0.76 | RET (0.58) | RET | |
| SCHEMBL29971635 | 0.75 | RET (0.66) | RET | |
| SCHEMBL20068897 | 0.75 | RET (0.66) | RET | |
| SCHEMBL22796030 | 0.75 | RET (0.68) | RET | |
| SCHEMBL31298329 | 0.74 | RET (0.52) | RET | |
| SCHEMBL31098118 | 0.74 | RET (0.68) | RET | |
| SCHEMBL31098123 | 0.74 | RET (0.68) | RET | |
| SCHEMBL18390416 | 0.74 | RET (0.68) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574235-B | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2019075092-A1 | PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE | EARY CHARLES TODD (US) | 2019-04-18 | — | — | WO | disclosed |
| WO-2019075114-A1 | FORMULATIONS COMPRISING 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZAB ICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE | REYNOLDS MARK (US) | 2019-04-18 | — | — | WO | disclosed |