Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909050 | 0.94 | PTPN11 (0.69) | PTPN11KCNH2EGFR | |
| SCHEMBL20909377 | 0.90 | PTPN11 (0.60) | PTPN11KCNH2EGFR | |
| SCHEMBL22594986 | 0.90 | PTPN11 (0.66) | PTPN11KCNH2EGFR | |
| SCHEMBL20909056 | 0.85 | PTPN11 (0.68) | PTPN11KCNH2EGFR | |
| SCHEMBL30787825 | 0.83 | PTPN11 (1.00) | PTPN11KCNH2EGFR | |
| SCHEMBL20899360 | 0.83 | PTPN11 (1.00) | PTPN11KCNH2EGFR | |
| SCHEMBL20909035 | 0.82 | PTPN11 (0.73) | PTPN11KCNH2 | |
| SCHEMBL20909053 | 0.81 | PTPN11 (0.50) | PTPN11KCNH2EGFR | |
| SCHEMBL20909371 | 0.79 | PTPN11 (0.72) | PTPN11KCNH2 | |
| SCHEMBL20909043 | 0.78 | PTPN11 (0.72) | PTPN11KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019075265-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2019-04-18 | — | — | WO | disclosed |