Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909438 | 0.91 | PTPN11 (0.54) | PTPN11 | |
| SCHEMBL24151308 | 0.90 | PTPN11 (0.52) | PTPN11 | |
| SCHEMBL20909327 | 0.89 | PTPN11 (0.53) | PTPN11 | |
| SCHEMBL20909300 | 0.86 | PTPN11 (0.71) | PTPN11 | |
| SCHEMBL20909299 | 0.86 | PTPN11 (0.57) | PTPN11 | |
| SCHEMBL20909324 | 0.86 | PTPN11 (0.57) | PTPN11 | |
| SCHEMBL19785615 | 0.85 | PTPN11 (0.56) | PTPN11 | |
| SCHEMBL24151067 | 0.85 | PTPN11 (0.52) | PTPN11 | |
| SCHEMBL26428946 | 0.84 | PTPN11 (0.51) | PTPN11 | |
| SCHEMBL20909292 | 0.83 | PTPN11 (0.53) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169913-A1 | SUBSTITUTED PYRAZINE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| WO-2019075265-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2019-04-18 | — | — | WO | disclosed |