Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 14/20 | 0.46 |
| ▸ | TTK | P33981 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909053 | 0.86 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL30787770 | 0.81 | PTPN11 (0.72) | PTPN11 | |
| SCHEMBL20899359 | 0.81 | PTPN11 (0.72) | PTPN11 | |
| SCHEMBL22594940 | 0.79 | PTPN11 (0.58) | PTPN11 | |
| SCHEMBL20909363 | 0.77 | PTPN11 (0.69) | PTPN11 | |
| SCHEMBL20909037 | 0.74 | PTPN11 (0.66) | PTPN11 | |
| SCHEMBL20909187 | 0.74 | PTPN11 (0.68) | PTPN11 | |
| SCHEMBL20909377 | 0.73 | PTPN11 (0.60) | PTPN11 | |
| SCHEMBL20909388 | 0.72 | PTPN11 (0.69) | PTPN11 | |
| SCHEMBL20909295 | 0.72 | PTPN11 (0.55) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019075265-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2019-04-18 | — | — | WO | disclosed |