Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094563 | 0.84 | SYK (0.41) | SYKTYK2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2499014 | 0.82 | SYK (0.62) | SYKMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16824916 | 0.81 | RXFP1 (0.44) | TYK2MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL20909768 | 0.79 | MAPK1 (0.45) | SYKTYK2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20910074 | 0.76 | MAPK1 (0.43) | SYKMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16120490 | 0.76 | LRRK2 (0.42) | SYKTYK2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12197611 | 0.76 | LRRK2 (0.42) | SYKTYK2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL16120663 | 0.75 | HTT (0.44) | SYKTYK2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20910312 | 0.73 | MAPT (0.39) | SYKMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17709583 | 0.69 | LRRK2 (0.38) | MAPK1LRRK2PIK3CAMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |