Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536182 | 0.87 | VEGFA (0.68) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL4938599 | 0.87 | VEGFA (0.56) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL18608789 | 0.87 | MEN1 (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL4156092 | 0.87 | VEGFA (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL2363123 | 0.87 | VEGFA (0.56) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL2858333 | 0.87 | TP53 (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL22550052 | 0.86 | VEGFA (0.53) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL23250104 | 0.86 | VEGFA (0.55) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL1433245 | 0.86 | POLB (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL21198803 | 0.86 | VEGFA (0.55) | VEGFAEGLN1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019074962-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS, INC. (US) | 2019-04-18 | — | — | WO | disclosed |