Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.49 |
| ▸ | BCR | P11274 | 16/20 | 0.49 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399457 | 0.94 | ABL1 (0.49) | ABL1BCREPHX2 | |
| SCHEMBL3396834 | 0.90 | HSD17B10 (0.51) | ABL1BCRMAPK1 | |
| SCHEMBL3402608 | 0.88 | EPHX2 (0.54) | ABL1BCREPHX2 | |
| SCHEMBL3396839 | 0.85 | ABL1 (0.55) | ABL1BCR | |
| SCHEMBL3403375 | 0.84 | ABL1 (0.56) | ABL1BCR | |
| SCHEMBL13821120 | 0.84 | ABL1 (0.56) | ABL1BCR | |
| SCHEMBL13821497 | 0.81 | ABL1 (0.49) | ABL1BCR | |
| SCHEMBL3399887 | 0.81 | ABL1 (0.49) | ABL1BCR | |
| SCHEMBL16331109 | 0.81 | ABL1 (0.62) | ABL1BCR | |
| SCHEMBL16363315 | 0.81 | HSD17B10 (0.42) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150593-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2019-04-24 | — | — | EP | claimed |