Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.73 |
| ▸ | BCR | P11274 | 19/20 | 0.73 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400298 | 0.88 | ABL1 (0.80) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3398664 | 0.84 | ABL1 (1.00) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400333 | 0.83 | ABL1 (0.73) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL13820275 | 0.83 | ABL1 (0.73) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400748 | 0.83 | ABL1 (0.73) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3398606 | 0.81 | ABL1 (0.76) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3396606 | 0.80 | ABL1 (0.80) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL19681282 | 0.80 | ABL1 (0.84) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3396836 | 0.80 | ABL1 (1.00) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3395255 | 0.79 | ABL1 (0.66) | ABL1BCRTTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150593-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2019-04-24 | — | — | EP | claimed |