Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SQOR | Q9Y6N5 | 9/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20921110 | 0.89 | RECQL (0.43) | RECQLKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL20920933 | 0.74 | TSHR (0.37) | ALDH1A1GAAMAPTTSHR | |
| SCHEMBL18135121 | 0.72 | KDM4E (0.49) | RECQLKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL20920942 | 0.71 | RECQL (0.43) | RECQLKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL20921073 | 0.71 | RECQL (0.43) | RECQLKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4075864 | 0.68 | RECQL (0.46) | RECQLKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL20921108 | 0.68 | MAPT (0.37) | GAAMAPTTSHR | |
| SCHEMBL16740891 | 0.67 | KDM4E (0.43) | RECQLKDM4ESQORPOLB | |
| SCHEMBL11932491 | 0.67 | CSNK2A1 (0.45) | GAACLK4 | |
| SCHEMBL24284162 | 0.66 | MAPT (0.36) | KDM4EMAPTL3MBTL1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | EZH2, BMI1, EED | RECQL 3447/4885KDM4E 27/4885ALDH1A1 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.