Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 13/20 | 0.61 |
| ▸ | PDE1A | P54750 | 6/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.61 |
| ▸ | PDE5A | O76074 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822462 | 0.87 | PDE1B (0.67) | PDE1BPDE1APDE1CPDE5AKDM4E | |
| SCHEMBL17142286 | 0.77 | PDE1B (0.52) | PDE1BPDE1APDE1CKMT2APDE4B | |
| SCHEMBL16822553 | 0.76 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE5AKDM4E | |
| SCHEMBL17142302 | 0.75 | PDE1B (0.52) | PDE1BPDE1APDE1C | |
| SCHEMBL16822550 | 0.72 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5AKDM4E | |
| SCHEMBL16822571 | 0.71 | PDE1B (0.55) | PDE1BPDE1APDE1CKDM4EMEN1 | |
| SCHEMBL16822534 | 0.71 | PDE1B (0.55) | PDE1BPDE1APDE1CKDM4EMEN1 | |
| SCHEMBL16822561 | 0.71 | PDE1B (0.55) | PDE1BPDE1APDE1CKDM4EMEN1 | |
| SCHEMBL16822569 | 0.71 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE5AKDM4E | |
| SCHEMBL16822501 | 0.68 | PDE1B (0.60) | PDE1BPDE1APDE1CPDE5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083607-B1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-04-24 | — | — | EP | disclosed |