SCHEMBL20928249

SCHEMBL20928249

N#Cc1ccc2c(c1)c1cc(C#N)ccc1n2-c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(-n4c5ccc(C#N)cc5c5cc(C#N)ccc54)cc3-n3c4ccc(C#N)cc4c4cc(C#N)ccc43)n2)c(-n2c3ccc(C#N)cc3c3cc(C#N)ccc32)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 10/20 0.39
ABCB1 P08183 4/20 0.39
ALDH1A1 P00352 4/20 0.37
CYP1A2 P05177 4/20 0.37
LMNA P02545 4/20 0.37
CLK4 Q9HAZ1 3/20 0.37
MEN1 O00255 3/20 0.37
CYP3A4 P08684 3/20 0.37
KMT2A Q03164 3/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2D6 P10635 2/20 0.37
TSHR P16473 2/20 0.37
HSD17B10 Q99714 2/20 0.37
CYP2C9 P11712 1/20 0.37
JAK2 O60674 1/20 0.36
PRKD3 O94806 1/20 0.36
ABL1 P00519 1/20 0.36
EGFR P00533 1/20 0.36
ERBB2 P04626 1/20 0.36
LCK P06239 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20928243 0.97 CYP1A2 (0.38) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20114540 0.93 ABCG2 (0.42) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20114545 0.92 CYP1A2 (0.38) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20114530 0.92 CYP1A2 (0.38) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL24125647 0.91 CYP1A2 (0.40) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20928247 0.91 ABCG2 (0.39) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL22171727 0.91 ABCG2 (0.40) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20928245 0.90 CYP1A2 (0.38) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL22243045 0.90 ABCG2 (0.37) ABCG2ABCB1ALDH1A1CYP1A2LMNA
SCHEMBL20114539 0.89 CYP1A2 (0.40) ABCG2ABCB1ALDH1A1CYP1A2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019076965-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-04-25 WO disclosed