SCHEMBL20929652

SCHEMBL20929652

COc1cccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)n3ncccc23)c1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 19/20 0.49
TYK2 P29597 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20929433 0.91 CHRM1 (0.59) CHRM1
SCHEMBL22264570 0.86 CHRM1 (0.47) CHRM1
SCHEMBL20929716 0.86 CHRM1 (0.51) CHRM1
SCHEMBL20929644 0.86 CHRM1 (0.47) CHRM1
SCHEMBL22264569 0.85 CHRM1 (0.46) CHRM1
SCHEMBL20929655 0.85 CHRM1 (0.48) CHRM1
SCHEMBL20929661 0.83 CHRM1 (0.58) CHRM1
SCHEMBL20929657 0.83 CHRM1 (0.49) CHRM1
SCHEMBL20929287 0.83 CHRM1 (0.52) CHRM1
SCHEMBL20929654 0.83 CHRM1 (0.53) CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3697790-B1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LTD (IN) 2023-01-18 EP claimed
US-11234979-B2 Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators SUVEN LIFE SCIENCES LIMITED (IN) 2022-02-01 US claimed
US-20200237761-A1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LIMITED (IN) 2020-07-30 US claimed
EP-3697790-B1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LTD (IN) 2023-01-18 EP disclosed
EP-3697790-B1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LTD (IN) 2023-01-18 EP disclosed
US-11234979-B2 Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators SUVEN LIFE SCIENCES LIMITED (IN) 2022-02-01 US disclosed
US-11234979-B2 Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators SUVEN LIFE SCIENCES LIMITED (IN) 2022-02-01 US disclosed
US-20200237761-A1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LIMITED (IN) 2020-07-30 US disclosed
US-20200237761-A1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LIMITED (IN) 2020-07-30 US disclosed
WO-2019077517-A1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS SUVEN LIFE SCIENCES LIMITED (IN) 2019-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200237761-A1 HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS CHRM1, CHRM2, CHRM3 CHRM1 1/4885TYK2 2163/4885
US-11234979-B2 Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators CHRM1, CHRM2, CHRM3 CHRM1 1/4885TYK2 2253/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.