Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.67 |
| ▸ | TNF | P01375 | 2/20 | 0.63 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | IL1B | P01584 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20437036 | 0.93 | CRBN (0.75) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL30503680 | 0.86 | CRBN (0.67) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL30503679 | 0.86 | CRBN (0.67) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL29024775 | 0.86 | CRBN (0.67) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL19451376 | 0.85 | CRBN (0.65) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL25280638 | 0.85 | CRBN (0.61) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL30351694 | 0.84 | CRBN (0.67) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL20811868 | 0.83 | CRBN (0.62) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL25231085 | 0.83 | CRBN (0.62) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL25227373 | 0.82 | CRBN (0.61) | CRBNDDB1TNFIKZF3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079701-A1 | HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITYFOR THE BROMODOMAIN OF BRD4 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-25 | — | — | WO | disclosed |