Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919599 | 0.90 | CDK1 (0.47) | CCNE2CCNE1CDK2TDP1CDK1 | |
| SCHEMBL19747594 | 0.76 | MAPT (0.47) | CCNE2CCNE1CDK2TDP1MAPT | |
| SCHEMBL19747188 | 0.74 | CCNE2 (0.47) | CCNE2CCNE1CDK2TDP1CDK1 | |
| SCHEMBL3953843 | 0.74 | APP (0.51) | CCNE2CCNE1CDK2MAPTGAA | |
| SCHEMBL21256170 | 0.73 | TP53 (0.41) | CCNE2CCNE1CDK2CDK1MAPT | |
| SCHEMBL26629826 | 0.73 | MAPK8 (0.46) | CDK2TDP1CDK1MAPTNPC1 | |
| SCHEMBL27466106 | 0.73 | MAPT (0.52) | CDK1MAPTGAAMEN1NPC1 | |
| SCHEMBL14432369 | 0.72 | IKBKB (0.41) | — | |
| SCHEMBL1674072 | 0.71 | ZAP70 (0.46) | CCNE2CCNE1CDK2TDP1CDK1 | |
| SCHEMBL27179661 | 0.70 | IKBKB (0.36) | CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006034-A1 | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3697789-B1 | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2019079469-A1 | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2019-04-25 | — | — | WO | disclosed |