Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | GPR17 | Q13304 | 8/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20935255 | 0.90 | APEX1 (0.55) | EGFRAPEX1PRSS1PRSS2PRSS3 | |
| SCHEMBL18509428 | 0.85 | EGFR (0.72) | EGFRAPEX1GPR17KDM4EALDH1A1 | |
| SCHEMBL20935027 | 0.81 | EGFR (0.56) | EGFRAPEX1GPR17KDM4EALDH1A1 | |
| SCHEMBL23226279 | 0.80 | GPR17 (0.71) | EGFRAPEX1GPR17 | |
| SCHEMBL19871264 | 0.79 | PRSS1 (0.43) | EGFRPRSS1PRSS2PRSS3KLK6 | |
| SCHEMBL20935034 | 0.77 | EGFR (0.55) | EGFRAPEX1GPR17KDM4EALDH1A1 | |
| SCHEMBL19872632 | 0.77 | GPR17 (0.74) | EGFRAPEX1GPR17KDM4EALDH1A1 | |
| SCHEMBL18509728 | 0.77 | GPR17 (0.72) | EGFRAPEX1GPR17KDM4EALDH1A1 | |
| SCHEMBL7369831 | 0.76 | APEX1 (0.55) | EGFRAPEX1FFAR1KDM4EALDH1A1 | |
| SCHEMBL20120069 | 0.76 | EGFR (0.51) | EGFRAPEX1GPR17KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550079-B2 | Artificial self-sufficient cytochrome P450s | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190119208-A1 | ARTIFICIAL SELF-SUFFICIENT CYTOCHROME P450S | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550079-B2 | Artificial self-sufficient cytochrome P450s | CYP4F2, CYP2F1, POR | EGFR 2865/4885APEX1 1660/4885GPR17 3737/4885 |
| US-20190119208-A1 | ARTIFICIAL SELF-SUFFICIENT CYTOCHROME P450S | CYP4F2, CYP2F1, POR | EGFR 2865/4885APEX1 1660/4885GPR17 3737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.