Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chenodiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 known ✓ | Q96RI1 | 7/20 | 1.00 |
| ▸ | GPBAR1 | Q8TDU6 | 14/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 1.00 |
| ▸ | ENPP2 | Q13822 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chenodiol SCHEMBL22079588 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24199134 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL23517166 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL22079179 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25337643 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24124587 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25397934 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24061005 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL23704676 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25337648 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3869192-B1 | METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE | HUMAN METABOLOMICS INST INC (CN) | 2026-05-13 | — | — | EP | claimed |
| US-20250258146-A1 | QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP | HUMAN METABOLOMICS INSTITUTE INC. (CN) | 2025-08-14 | — | — | US | claimed |
| EP-4537111-A2 | MULTI-OMICS ASSESSMENT | Prognomiq Inc (US) | 2025-04-16 | — | — | EP | claimed |
| CN-119816897-A | Multiple study assessment | 普罗科技有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-116396349-B | Method for purifying isoursodeoxycholic acid | 常德云港生物科技股份有限公司 | 2024-09-13 | — | — | CN | claimed |
| US-20240263251-A1 | COMPOSITIONS AND METHODS FOR PROVIDING SECONDARY BILE ACIDS TO A SUBJECT | FINCH THERAPEUTICS HOLDINGS LLC (US) | 2024-08-08 | — | — | US | claimed |
| EP-4386090-A1 | METHOD FOR DETERMINING AND IMPROVING THE POTENTIAL EFFICACY OF ANTICANCER TREATMENT | ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (FR) | 2024-06-19 | — | — | EP | claimed |
| US-20240183845-A1 | BILE ACID METABOLITES FOR DIAGNOSING AND TREATING DEPRESSIVE DISORDERS | KADDURAH DAOUK RIMA F (US) | 2024-06-06 | — | — | US | claimed |
| WO-2023240046-A2 | MULTI-OMICS ASSESSMENT | PrognomIQ, Inc. (US) | 2023-12-14 | — | — | WO | claimed |
| US-20230375534-A1 | MEANS AND METHODS TO DIAGNOSE GUT FLORA DYSBIOSIS AND INFLAMMATION | VIB VZW (BE) | 2023-11-23 | — | — | US | claimed |
| US-6627197-B2 | Using variant of a protein synthesis inactivating toxin wherein a viral protease cleavage site is interposed between A and B chains; treatment of human immunodeficiency virus | BECHTEL BWXT IDAHO, LLC | 2003-09-30 | — | — | US | claimed |
| US-6589943-B2 | Made by dissolving an amphiphilic heparin derivative comprising heparin conjugated to bile acids, sterols, or alkanoic acids in a water phase, dispersing the water phase in an organic phase to form an emulsion, drying the emulsion | MEDIPLEX CORPORATION, KOREA (KR) | 2003-07-08 | — | — | US | claimed |
| WO-2003004685-A2 | SOLUBLE STEROIDAL PEPTIDES FOR NUCLEIC ACID DELIVERY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2003-01-16 | — | — | WO | claimed |
| WO-2002089820-A1 | FORMULATION OF AMPHIPHILIC HEPARIN DERIVATIVES FOR ENHANCING MUCOSAL ABSORPTION | MEDIPLEX CORPORATION (KR) | 2002-11-14 | — | — | WO | claimed |
| US-20020094334-A1 | Selective destruction of cells infected with human immunodeficiency virus | BATTELLE ENERGY ALLIANCE, LLC | 2002-07-18 | — | — | US | claimed |
| US-20020013292-A1 | Formulation of amphiphilic heparin derivatives for enhancing mucosal absorption | MEDIPLEX CORPORATION KOREA (KR) | 2002-01-31 | — | — | US | claimed |
| US-20020010153-A1 | Oral delivery of macromolecules | MEDIPLEX CORPORATION (KR) | 2002-01-24 | — | — | US | claimed |
| WO-2001060393-A1 | SELECTIVE DESTRUCTION OF CELLS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS | BECHTEL BWXT IDAHO, LLC (US) | 2001-08-23 | — | — | WO | claimed |
| US-6245753-B1 | Amphiphilic polysaccharide derivatives | MEDIPLEX CORPORATION, KOREA (KR) | 2001-06-12 | — | — | US | claimed |
| WO-1999061481-A1 | AMPHIPHILIC POLYSACCHARIDE DERIVATIVES | MEDIPLEX CORPORATION, KOREA (KR) | 1999-12-02 | — | — | WO | claimed |