Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062209 | 1.00 | BTK (0.51) | BTKGAACTSKCA1CA2 | |
| SCHEMBL20331988 | 1.00 | BTK (0.51) | BTKGAACTSKCA1CA2 | |
| SCHEMBL13233377 | 0.91 | BTK (0.53) | BTKGAACTSKCA1CA2 | |
| SCHEMBL2226232 | 0.90 | BTK (0.56) | BTKGAACTSKCA1CA2 | |
| SCHEMBL12439636 | 0.90 | BTK (0.56) | BTKGAACTSKCA1CA2 | |
| SCHEMBL2226229 | 0.90 | BTK (0.56) | BTKGAACTSKCA1CA2 | |
| SCHEMBL21553267 | 0.88 | BTK (0.55) | BTKGAACTSKCA1CA2 | |
| SCHEMBL28551448 | 0.88 | GAA (0.50) | BTKGAACTSKCA1CA2 | |
| SCHEMBL20377683 | 0.85 | GAA (0.56) | BTKGAACTSKCA1CA2 | |
| SCHEMBL21553263 | 0.85 | BTK (0.55) | BTKGAACTSKCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237416-B1 | POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE | GILEAD SCIENCES INC (US) | 2019-05-01 | — | — | EP | disclosed |