Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14631159 | 0.87 | TNK2 (0.48) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL18283348 | 0.87 | TNK2 (0.48) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL16748869 | 0.87 | TNK2 (0.60) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL18345263 | 0.87 | TNK2 (0.60) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL20962359 | 0.86 | BTK (0.51) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL20962403 | 0.86 | BTK (0.47) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL14630474 | 0.84 | TNK2 (0.47) | TNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL20962424 | 0.84 | BTK (0.47) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL20962382 | 0.84 | TNK2 (0.46) | BTKTNK2FGFR1FGFR4FGFR3 | |
| SCHEMBL20962334 | 0.83 | TNK2 (0.53) | BTKTNK2FGFR1FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948458-B1 | BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-05-01 | — | — | EP | disclosed |