Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562318 | 0.83 | TDP1 (0.46) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL21065336 | 0.82 | TDP1 (0.52) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL1696844 | 0.81 | TDP1 (0.53) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL22849847 | 0.81 | TDP1 (0.44) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL4573154 | 0.81 | TDP1 (0.44) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL21413949 | 0.81 | TDP1 (0.41) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL1696880 | 0.80 | TDP1 (0.43) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL46654 | 0.79 | TDP1 (0.58) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL3043987 | 0.79 | MEN1 (0.44) | TDP1MEN1KMT2AGAAMAOA | |
| SCHEMBL20285497 | 0.79 | TDP1 (0.46) | TDP1MEN1KMT2AGAAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858359-B2 | Heterocyclic ring derivatives useful as SHP2 inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-12-08 | — | — | US | disclosed |
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858359-B2 | Heterocyclic ring derivatives useful as SHP2 inhibitors | PTPRJ, PTPN22, PTPRCAP | TDP1 2332/4885MEN1 3187/4885KMT2A 1311/4885 |
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN22, PTPN1, PTPRJ | TDP1 2536/4885MEN1 3099/4885KMT2A 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.