Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23489076 | 0.86 | — | — | |
| SCHEMBL19704078 | 0.79 | JAK2 (0.36) | JAK2JAK1KDM1AMAOBTSHR | |
| SCHEMBL21166079 | 0.78 | — | — | |
| SCHEMBL19766337 | 0.75 | CYP1A2 (0.36) | TSHR | |
| SCHEMBL14768781 | 0.75 | KDM1A (0.38) | KDM1AMAOB | |
| SCHEMBL19704074 | 0.74 | KCNH2 (0.46) | JAK2JAK1KDM1AMAOBTSHR | |
| SCHEMBL24942651 | 0.74 | CYP1A2 (0.36) | JAK2JAK1KDM1AMAOBTSHR | |
| SCHEMBL18642963 | 0.71 | TSHR (0.37) | JAK2JAK1KDM1AMAOBTSHR | |
| SCHEMBL27480808 | 0.71 | TSHR (0.37) | JAK2JAK1KDM1AMAOBTSHR | |
| SCHEMBL21166083 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN22, PTPN1, PTPRJ | JAK2 73/4885JAK1 132/4885KDM1A 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.