⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18390365 | 0.74 | PTPN11 (0.34) | — | |
| SCHEMBL23592937 | 0.71 | — | — | |
| SCHEMBL18390355 | 0.64 | PTPN11 (0.39) | — | |
| SCHEMBL25680626 | 0.64 | — | — | |
| SCHEMBL22142443 | 0.61 | — | — | |
| SCHEMBL20065982 | 0.61 | — | — | |
| SCHEMBL24839731 | 0.61 | — | — | |
| SCHEMBL18390360 | 0.60 | — | — | |
| SCHEMBL18392396 | 0.58 | PTPN11 (0.43) | — | |
| SCHEMBL24080953 | 0.58 | PTPN11 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127373-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2019-05-02 | — | — | US | disclosed |