Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054731 | 1.00 | HSD17B10 (0.34) | HSD17B10HPGDCHRM2CHRM1CHRM3 | |
| SCHEMBL17819531 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17820403 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL2054728 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17819527 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17819724 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17819812 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL2056396 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17819720 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL17820406 | 0.92 | HSD17B10 (0.41) | HSD17B10HPGDLMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899294-B1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME (GB) | 2015-03-18 | — | — | EP | disclosed |
| US-8163956-B2 | Inhibitors of GLYT1 transporters | MERCK SHARP & DOHME CORP. (US) | 2012-04-24 | — | — | US | disclosed |