Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.35 |
| ▸ | CDK2 | P24941 | 10/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KIF5B | P33176 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ETV6 | P41212 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15006972 | 0.93 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL20640 | 0.93 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL21922 | 0.93 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15007359 | 0.92 | CFTR (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15007311 | 0.91 | CHEK1 (0.35) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15006919 | 0.89 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15031480 | 0.89 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15006918 | 0.89 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL15007221 | 0.88 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 | |
| SCHEMBL22015 | 0.88 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |