Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.72 |
| ▸ | AURKA | O14965 | 15/20 | 0.72 |
| ▸ | TEK | Q02763 | 15/20 | 0.72 |
| ▸ | MET | P08581 | 13/20 | 0.72 |
| ▸ | LCK | P06239 | 12/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.72 |
| ▸ | LYN | P07948 | 3/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | FGR | P09769 | 1/20 | 0.72 |
| ▸ | FLT1 | P17948 | 3/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.63 |
| ▸ | FLT4 | P35916 | 2/20 | 0.63 |
| ▸ | PDXK | O00764 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.63 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.63 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837779 | 0.93 | KDR (0.74) | KDRAURKATEKMETLCK | |
| SCHEMBL2096054 | 0.90 | KDR (0.81) | KDRAURKATEKMETLCK | |
| SCHEMBL28430564 | 0.89 | KDR (0.73) | KDRAURKATEKMETLCK | |
| SCHEMBL2098714 | 0.88 | KDR (0.76) | KDRAURKATEKMETLCK | |
| SCHEMBL2098854 | 0.87 | KDR (0.75) | KDRAURKATEKMETLCK | |
| SCHEMBL2097763 | 0.85 | KDR (0.83) | KDRAURKATEKMETLCK | |
| SCHEMBL2746021 | 0.85 | KDR (1.00) | KDRAURKATEKMETLCK | |
| SCHEMBL2098367 | 0.84 | KDR (0.70) | KDRAURKATEKMETLCK | |
| SCHEMBL2101349 | 0.83 | KDR (0.81) | KDRAURKATEKMETLCK | |
| SCHEMBL2098716 | 0.83 | KDR (0.77) | KDRAURKATEKMETLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125777-B1 | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | ADVENCHEN LAB LLC (US) | 2013-04-10 | — | — | EP | claimed |
| US-8163923-B2 | Benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate; cancers associated with protein tyrosine kinases | ADVENCHEN LABORATORIES, LLC (US) | 2012-04-24 | — | — | US | claimed |