Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.52 |
| ▸ | PNP | P00491 | 9/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310021 | 0.75 | FGFR1 (0.73) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL5084758 | 0.75 | PNP (0.67) | FGFR1FGFR2PNPKDM4EMEN1 | |
| 8-Aminoguanine SCHEMBL21761 | 0.71 | PNP (1.00) | FGFR1FGFR2PNPKDM4EMEN1 | |
| SCHEMBL9116 | 0.70 | PNP (0.73) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL10644156 | 0.69 | PNP (0.59) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL1286943 | 0.69 | FGFR1 (1.00) | FGFR1FGFR2PNPMEN1ALDH1A1 | |
| SCHEMBL7875967 | 0.67 | FGFR1 (0.69) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL1286938 | 0.67 | FGFR1 (0.72) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL15542828 | 0.66 | FGFR1 (0.70) | FGFR1FGFR2PNPFGFR3KDM4E | |
| SCHEMBL11610791 | 0.66 | FGFR1 (0.62) | FGFR1FGFR2PNPFGFR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730298-B1 | SPECIFIC SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | EPFL ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-8163479-B2 | Specific substrates for O6-alkylguanine-DNA alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-04-24 | — | — | US | disclosed |