Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15226935 | 1.00 | HRH3 (0.42) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL29573633 | 1.00 | HRH3 (0.42) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL20975574 | 0.99 | MAPK1 (0.43) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL20975573 | 0.99 | MAPK1 (0.43) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| Water SCHEMBL21838307 | 0.99 | HRH3 (0.41) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| Water SCHEMBL21838308 | 0.99 | HRH3 (0.41) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL2721736 | 0.91 | DRD3 (0.46) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL900698 | 0.89 | HRH3 (0.41) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL15227129 | 0.89 | HRH3 (0.43) | HRH3CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL15227288 | 0.88 | HRH3 (0.40) | HRH3CHRM2HTR1AADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281839-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2022-09-08 | — | — | US | claimed |
| US-11306069-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | BIOPROJET (FR) | 2022-04-19 | — | — | US | claimed |
| EP-3486243-B1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2020-04-15 | — | — | EP | claimed |
| EP-3486243-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | Bioprojet (FR) | 2019-05-22 | — | — | EP | claimed |
| US-20190144421-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2019-05-16 | — | — | US | claimed |
| US-12134608-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | BIOPROJET (FR) | 2024-11-05 | — | — | US | disclosed |
| US-20220281839-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2022-09-08 | — | — | US | disclosed |
| US-11306069-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | BIOPROJET (FR) | 2022-04-19 | — | — | US | disclosed |
| EP-3486243-B1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2020-04-15 | — | — | EP | disclosed |
| EP-3486243-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | Bioprojet (FR) | 2019-05-22 | — | — | EP | disclosed |
| US-20190144421-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144421-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | HRH4, HRH3, HRH1 | HRH3 2/4885CHRM2 49/4885HTR1A 77/4885 |
| US-20220281839-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | HRH4, HRH3, HRH1 | HRH3 2/4885CHRM2 76/4885HTR1A 58/4885 |
| US-12134608-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | HRH4, HRH3, HRH1 | HRH3 2/4885CHRM2 76/4885HTR1A 58/4885 |
| US-11306069-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | HRH4, HRH3, HRH1 | HRH3 2/4885CHRM2 49/4885HTR1A 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.