Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | MITF | O75030 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 8/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | POLB | P06746 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | GFER | P55789 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363344 | 0.90 | HTT (0.87) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL2353462 | 0.89 | HTT (0.86) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL20979224 | 0.89 | HTT (0.86) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL2362625 | 0.89 | HTT (1.00) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL2362550 | 0.88 | HTT (0.76) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL2363639 | 0.88 | HTT (0.78) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL18568448 | 0.88 | MAPK1 (0.74) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL18568486 | 0.88 | NPSR1 (0.73) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL9995982 | 0.88 | TP53 (0.79) | HTTL3MBTL1MAPK1MITFTP53 | |
| SCHEMBL2363074 | 0.87 | HTT (0.77) | HTTL3MBTL1MAPK1MITFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154966-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | US HEALTH (US) | 2019-05-08 | — | — | EP | disclosed |