Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098605 | 0.89 | KDM4E (0.43) | RAB9ANPC1MEN1KMT2ALMNA | |
| SCHEMBL2099883 | 0.81 | S1PR1 (0.31) | — | |
| SCHEMBL1754307 | 0.80 | MAPT (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2098958 | 0.80 | MAPT (0.39) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2098962 | 0.78 | CYP3A4 (0.38) | — | |
| SCHEMBL2055448 | 0.78 | MAPT (0.42) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2099846 | 0.77 | CNR2 (0.38) | RAB9ANPC1MEN1KMT2ANPSR1 | |
| SCHEMBL2099916 | 0.76 | PLK1 (0.38) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2099401 | 0.76 | DOT1L (0.38) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2098617 | 0.76 | POLB (0.38) | MEN1KMT2ATP53CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163911-B2 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-24 | — | — | US | disclosed |