Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979540 | 0.90 | KDM1A (0.60) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979719 | 0.87 | KDM1A (0.67) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979640 | 0.83 | KDM1A (0.69) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL15772540 | 0.81 | KDM1A (0.77) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL15772536 | 0.81 | KDM1A (0.77) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL15772539 | 0.81 | KDM1A (0.77) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL14696964 | 0.80 | KDM1A (0.76) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL14696963 | 0.80 | KDM1A (0.76) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL14696962 | 0.80 | KDM1A (0.76) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979484 | 0.79 | KDM1A (0.63) | KDM1ABRD4CYP3A4CYP2C9BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |