Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 9/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | BRD2 | P25440 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979576 | 0.92 | KDM1A (0.72) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979477 | 0.92 | KDM1A (0.59) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979457 | 0.88 | KDM1A (0.55) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979632 | 0.86 | KDM1A (0.50) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979484 | 0.83 | KDM1A (0.63) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979525 | 0.83 | KDM1A (0.57) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979547 | 0.82 | KDM1A (0.62) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979521 | 0.82 | KDM1A (0.52) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979639 | 0.81 | KDM1A (0.58) | KDM1ABRD4CYP3A4CYP2C9BRD2 | |
| SCHEMBL20979719 | 0.81 | KDM1A (0.67) | KDM1ABRD4CYP3A4CYP2C9BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744330-B1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIV UTAH RES FOUND (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |