Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 5/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564303 | 0.82 | MAOB (0.43) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL9987222 | 0.79 | CNR1 (0.44) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL20564322 | 0.78 | CNR2 (0.43) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL20980452 | 0.78 | CYP17A1 (0.41) | CNR1CNR2NPSR1NPC1RAB9A | |
| SCHEMBL24738071 | 0.76 | APP (0.50) | SMN1; SMN2ALDH1A1LMNAAPPPDE2A | |
| SCHEMBL6401853 | 0.76 | APP (0.50) | SMN1; SMN2ALDH1A1LMNAAPPPDE2A | |
| SCHEMBL3196355 | 0.75 | CNR1 (0.43) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL31514820 | 0.75 | CNR1 (0.43) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL22323930 | 0.75 | APP (0.50) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL31517985 | 0.75 | NPC1 (0.46) | SMN1; SMN2ALDH1A1LMNAAPPPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135793-A1 | HETEROCYCLIC INHIBITORS OF KDM5 FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135793-A1 | HETEROCYCLIC INHIBITORS OF KDM5 FOR THE TREATMENT OF DISEASE | KDM5A, KDM5B, KDM5C | SMN1; SMN2 2544/4885ALDH1A1 1687/4885LMNA 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.