Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.74 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.64 |
| ▸ | BRD1 | O95696 | 1/20 | 0.64 |
| ▸ | CCL2 | P13500 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | TAF1 | P21675 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | BRD2 | P25440 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.64 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.64 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.64 |
| ▸ | EP300 | Q09472 | 1/20 | 0.64 |
| ▸ | BPTF | Q12830 | 1/20 | 0.64 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.64 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.64 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.64 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.64 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.64 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456353 | 1.00 | BRD4 (0.74) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983266 | 0.90 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL21649918 | 0.90 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL19456317 | 0.90 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983263 | 0.90 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983297 | 0.90 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL21024098 | 0.87 | BRD4 (0.55) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL21023958 | 0.87 | BRD4 (0.87) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983264 | 0.87 | BRD4 (0.87) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL21023792 | 0.87 | BRD4 (0.87) | BRD4TRIM24BRD1CCL2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10583112-B2 | Benzo[b]furans as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2020-03-10 | — | — | US | claimed |
| US-20190151279-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-05-23 | — | — | US | claimed |
| US-10583112-B2 | Benzo[b]furans as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2020-03-10 | — | — | US | disclosed |
| US-20190151279-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10583112-B2 | Benzo[b]furans as bromodomain inhibitors | BRD4, BRD3, BRD2 | BRD4 1/4885TRIM24 3150/4885BRD1 4/4885 |
| US-20190151279-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD2 | BRD4 1/4885TRIM24 3150/4885BRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.