Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098616 | 1.00 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1833028 | 0.89 | MTOR (0.78) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1833024 | 0.89 | MTOR (0.78) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL2101536 | 0.87 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL2101526 | 0.87 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL15189881 | 0.87 | MTOR (0.63) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1840217 | 0.82 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1840214 | 0.82 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1829583 | 0.82 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 | |
| SCHEMBL1829587 | 0.82 | MTOR (0.65) | MTORKCNH2RPTORMLST8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | claimed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | claimed |
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | disclosed |